What drugs are metabolized by CYP2E1?
What drugs are metabolized by CYP2E1?
CYP2E1 is an enzyme that particularly participates in the metabolism of endogenous substrates, including acetone and fatty acids (abundant in the brain) [26] and exogenous compounds such as anesthetics, ethanol, nicotine, acetaminophen, acetone, aspartame, chloroform, chlorzoxazone, tetrachloride, and some …
What is cytochrome P450 2E1?
Cytochrome P450 (P450) 2E1 is the major P450 enzyme involved in ethanol metabolism. That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. The level of P450 2E1 may have relevance in the rates of oxidation of drugs, particularly acetaminophen and anesthetics.
Is CYP2E1 an enzyme?
Catalase and cytochrome P450 2E1(CYP2E1) represent the major enzymes in the CNS that catalyze ethanol oxidation. CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions.
What induces CYP2E1?
Our observations suggested that ethanol induces ROS production (through CYP2E1-mediated ethanol metabolism), leading to the induction of CYP2E1, which further produces ROS, causing cell apoptosis and death.
Where is CYP2E1 found?
the liver
CYP2E1 is mainly found in the liver but significant amounts are also found in most organs, including the brain (60). CYP2E1 is expressed mainly in the hepatocytes of the liver, however, significant amounts are also found in the Kupffer cells (61), and hepatocyte and Kupffer cell CYP2E1 are inducible e.g. by ethanol.
Is omeprazole a CYP3A4 inhibitor?
Omeprazole (OMP), which is metabolized by CYP2C19 and CYP3A4 (Andersson et al., 1994), is also an in vivo inhibitor of these two enzymes (Soons et al., 1992; Funck-Brentano et al., 1997; Yu et al., 2001; Angiolillo et al., 2011).
Is CYP2E1 an alcohol dehydrogenase?
The liver metabolizes alcohol using alcohol dehydrogenase (ADH) and cytochrome P450 2E1 (CYP2E1). Both enzymes metabolize ethanol into acetaldehyde, but CYP2E1 activity also results in the production of reactive oxygen species (ROS) that promote oxidative stress.
Does alcohol induce CYP2E1?
The induction of CYP2E1 by alcohol appears to be through translational, post-translational (protein stabilization), and transcriptional mechanisms. At low concentrations of alcohol, CYP2E1 exhibits increasing activity and increased protein stability.
Is CYP2E1 in the liver?
CYP2E1 is mainly found in the liver but significant amounts are also found in most organs, including the brain (60). CYP2E1 is expressed mainly in the hepatocytes of the liver, however, significant amounts are also found in the Kupffer cells (61), and hepatocyte and Kupffer cell CYP2E1 are inducible e.g. by ethanol.