What are the long term side effects of FOLFOX chemotherapy?

Hand/foot numbness/tingling appeared to be the longest lasting side-effects for those treated with oxaliplatin. The odds of hand numbness/tingling were significantly greater for the FLOX group during therapy and, while no longer significant at 18 months, were significantly greater at the long-term endpoint.

How toxic is FOLFOX?

The most common toxicities were abnormal kidney function (61.7%), neuropathy (54.9%), and cardiovascular-related side effects (hypertension, hypotension, thromboembolism, cardiac arrest; 51.4%). Gastrointestinal (GI) toxicities, including nausea, vomiting, and diarrhea, were recorded in 44% of patients.

How long do FOLFOX side effects last?

Patients usually say that they are at their best during the first 3 days after chemo. After that, you may have a loss of energy and experience a general feeling of being unwell. This feeling of being unwell usually last for 4 to 7 days after treatment, and can continue to worsen after each cycle of treatment.

What is a unique toxicity of oxaliplatin?

Although oxaliplatin by itself has only mild hematologic and gastrointestinal side effects, its clinically dominating toxicity affects the peripheral sensory nervous system in the form of 2 distinct types of neurotoxicity: (1) a unique, frequent, acute sensory neuropathy that is triggered or aggravated by exposure to …

How can I reduce the side effects of oxaliplatin?

Your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

How long does it take for oxaliplatin to leave your system?

The first elimination half-life (t1/2) for cisplatin was 5.02 months and the second 37.0 months. For oxaliplatin, these half-lifes were 1.37 and 535 months.

Does FOLFOX shrink tumors?

FOLFOX chemo is given to shrink tumors and help decrease symptoms for a colon cancer patient. If the disease is not metastatic, it is commonly given with the goal of cure.

How long does it take to recover from FOLFOX?

Nausea and vomiting are common with FOLFOX treatment. It is generally the worst for the first 12 to 48 hours after treatment. It often gets better in 3 to7 days.

Do FOLFOX side effects get worse?

Side effects can vary as to how often and how severe they are from person to person. Some side effects are more serious than others – contact your advice line if you have severe side effects, if they aren’t getting better or are getting worse. FOLFOX is a combination of chemotherapy drugs used to treat bowel cancer.

Will I lose my hair with oxaliplatin?

You could lose all your hair. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer. It may grow back a different colour or be curlier than before.

Is oxaliplatin a strong chemo?

Oxaliplatin is considered the most neurotoxic chemotherapy, and at the origin of peripheral neuropathies.

How effective is FOLFOX chemotherapy?

Abstract. 5-Fluorouracil (5FU),Folinic acid (FA),and Oxaliplatin (FOLFOX) or 5FU,FA,and Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer.

Does FOLFOX cause what percent of neutropenia?

Ninety percent of the patients experienced any dose-limiting toxicity (DLT), while 58 % of the patients had a neutropenia-related DLT. There were no documented episodes of FN. Granulocyte colony-stimulating factor (GCSF) was used in 10 % of the patients. Median relative dose intensity (RDI) was 81 and 85 % for oxaliplatin and 5-FU, respectively.

Does FOLFOX cause neutropenia?

Purpose: Adjuvant folinic acid, fluorouracil, and oxaliplatin (FOLFOX) chemotherapy for resected high-risk colon cancer is associated with a low risk of febrile neutropenia (FN). Neutropenia, however, is a common cause of dose modification or delay with unknown consequences on outcomes. We examined the effect of neutropenia-related and other dose-limiting toxicities and relative dose intensity of oxaliplatin and 5-FU, on relapse-free and overall survival in patients treated with FOLFOX

What is in FOLFOX chemotherapy?

Folfox chemotherapy can be used to treat certain types of colon cancer. FOLFOX chemotherapy is a promising treatment option for some types of colon and rectum cancers. Three drugs, folinic acid, fluorouracil, and oxaliplatin, are used in combination to destroy existing tumors and stop the spread of cancer to nearby cells.